The soybean cultivar SCEL-1 shows potent anti-photoaging effects in a UV-induced three-dimensional human skin and hairless mouse model

Abstract Soybean ( Glycine max ) is one of the major sources nutrition and used as a raw material for food source feed livestock. The efficacy soybeans on skin health includes their ability to reduce wrinkles pigmentation increase elasticity moisture content. Black soybean has been consumed worldwide long time, especially in Korea, medicinal against several disorders related skin. To evaluate whether its effect different based cultivar soybeans, three black cultivars collected Core collection Elite Line-1 (SCEL-1), Chung Ja-3 (CJ-3) Won Heuk (WH), were selected compare improving photoaging induced by ultraviolet rays (UVs). We found that SCEL-1 exhibited best among tested, treatment with this extract significantly reduced expression matrix metalloproteinase-1 (MMP-1), preventing degradation collagen 3D human model. In addition, application improved wrinkle- photoaging-related symptoms, such epidermal thickening, deficiency immune cell infiltration, an animal model established UV irradiation. Procyanidin B2 epicatechin isolated from inhibited MMP-1 biosynthesis UVB-irradiated dermal fibroblasts, these two components are likely more attenuated photoaging. Therefore, our results indicated exhibits good anti-wrinkle effects compared other cultivars, suggesting it represents excellent agent anti-photoaging.